Faculty

Research interest: bridging basic and clinical research that ultimately yields novel translational efforts in urologic oncology, yielding new paradigms for protein post translational modification and drug resistance in cancer cells, advance the understanding of cancer biology and providing opportunities for innovative cancer therapeutics. Current research program focuses on understanding the mechanisms of therapy resistance and progression in lethal prostate cancer with specialized focus on drug development for the treatment of prostate cancer. Interests include nuclear receptors, chaperone protein modification, ubiquitin proteasome regulation, steroid hormone biosynthesis and metabolism, clinical translational research and tumor immunology.

Research interest: Neuroimmunology and the role of microglia in canine and feline CNS health and disease, with a specific focus on the role of microglia in primary brain tumorigenesis.

Research interests: development of the human immune system and interaction of that system with agents of chronic infection such as the human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Most recent studies include development of Th17 cells, regulatory T cells (T-regs), and antigen-presenting cells in the mucosal immune system. Interested in the relationship between variable development of such immune cells and variable control over chronic infectious diseases, and the interactions between the normal gut microflora, pathogenic organisms, and immune cells within the intestine.

Research interests: Therapeutic Antibodies, Cancer Immunotherapy, Tumor Cell-death, Antibody-directed SARS-CoV2 targeting.

Research Interests: Regenerative medicine, microbiome studies, clinical trials, and developing next-generation tools that can predict/assess response to IBD therapies.

Research Interests: Genetics of autoimmunity and autoimmune phenotypes. The primary emphasis is on investigating mouse models of spontaneous polygenic autoimmune syndromes including Type one diabetes, Primary Biliary Cirrhosis, Systemic Lupus Erythematosis and Relapsing Polychondritis.

Research interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.

Research interests: mechanisms by which the environment influences susceptibility to immune-mediated disease; identify the mechanisms by which AhR activation leads to divergent CD4+ T cell fates, and test the hypothesis that the interaction between diverse AhR ligands, the host immune system, and the microbiome influences susceptibility to type 1 diabetes.

Research Interests: Our laboratory is dedicated to the study of tumors that avoid recognition and elimination by the human immune system. We combine modulation of the immune system in the tumor environment with active immunization to treat metastatic cancer. This work involves design, development and testing of peptide immunogens from tumor specific and tumor associated antigens.