Research Interests: Genetics of autoimmunity and autoimmune phenotypes. The primary emphasis is on investigating mouse models of spontaneous polygenic autoimmune syndromes including Type one diabetes, Primary Biliary Cirrhosis, Systemic Lupus Erythematosis and Relapsing Polychondritis.
Research interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.
Research interests: mechanisms by which the environment influences susceptibility to immune-mediated disease; identify the mechanisms by which AhR activation leads to divergent CD4+ T cell fates, and test the hypothesis that the interaction between diverse AhR ligands, the host immune system, and the microbiome influences susceptibility to type 1 diabetes.
Research Interests: I am interested in the mechanism whereby fusion genes are created. Such genes are classically the driving element in leukemia. However, their significance is expanding to a wider field and such fused genes have been implicated in the development of prostate cancer (TMPRSS2-ERG). Understanding the mechanism behind their creation opens possibilities to suppress the disease they cause.
Research Interests: Development of immune-based therapeutics for B cell malignancies. B lymphocyte signal transduction abnormalities; their role in human disease.
Research Interests: Our laboratory is dedicated to the study of tumors that avoid recognition and elimination by the human immune system. We combine modulation of the immune system in the tumor environment with active immunization to treat metastatic cancer. This work involves design, development and testing of peptide immunogens from tumor specific and tumor associated antigens.
Research Interests: Immunopathology, neuroimmunology, and the cellular and molecular basis of autoimmunity. Current research addresses the biological aspects of autism spectrum disorders including immune function, cellular mechanisms of immune dysregulation, and autoimmunity.
Research Interests: My research group studies interactions between bacterial pathogens and the innate immune system. We are particularly interested in how bacterial virulence factors interact with the host to evade immune clearance and elicit pathology.
Research Interests: Molecular characterization of food allergens associated with life-threatening anaphylactic reactions. Effect of seed polyphenolics on immune response and the possible role in development of food allergy to peanuts and tree nuts. Cross-reactivity of a food allergy.