Research Interests: Regenerative medicine, microbiome studies, clinical trials, and developing next-generation tools that can predict/assess response to IBD therapies.
Research Interests: Immune modulation by environmental factors (natural glycans such as human milk glycans and pathogen components) and the impact on inflammatory diseases (autoimmune diseases and cancers).
Research Interests: the molecular cell biology and biochemistry of malaria parasite transmission, functional characterization of the immunological crosstalk and cell signaling that occurs between the mosquito and the mammalian host during bloodfeeding, and the impact of endemic co-infections on malaria parasite development and transmission.
Research Interests: Genetics of autoimmunity and autoimmune phenotypes. The primary emphasis is on investigating mouse models of spontaneous polygenic autoimmune syndromes including Type one diabetes, Primary Biliary Cirrhosis, Systemic Lupus Erythematosis and Relapsing Polychondritis.
Research interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.
Research interests: mechanisms by which the environment influences susceptibility to immune-mediated disease; identify the mechanisms by which AhR activation leads to divergent CD4+ T cell fates, and test the hypothesis that the interaction between diverse AhR ligands, the host immune system, and the microbiome influences susceptibility to type 1 diabetes.
Research Interests: I am interested in the mechanism whereby fusion genes are created. Such genes are classically the driving element in leukemia. However, their significance is expanding to a wider field and such fused genes have been implicated in the development of prostate cancer (TMPRSS2-ERG). Understanding the mechanism behind their creation opens possibilities to suppress the disease they cause.
Research Interests: Development of immune-based therapeutics for B cell malignancies. B lymphocyte signal transduction abnormalities; their role in human disease.
Research Interests: Our laboratory is dedicated to the study of tumors that avoid recognition and elimination by the human immune system. We combine modulation of the immune system in the tumor environment with active immunization to treat metastatic cancer. This work involves design, development and testing of peptide immunogens from tumor specific and tumor associated antigens.