Research Interests: Novel treatments and therapeutic strategies for inflammatory arthritis and immune bone loss. Our laboratory studies the interface between the skeletal and immune systems, a newly emerging area of research called "osteoimmunology".
Research interests: Evaluating the immune response in children with autism and to examine the interface between the immune system and the central nervous system.
Research Interests: The Baumgarth Lab investigates the signals that drive a protective B cell response to influenza infection and how these responses might be derailed during infection with Borrelia burgdorferi, the Lyme Disease agent. We are interested also in understanding the development, role, and function of B-1 cells in infectious immunity and how natural IgM regulates the adaptive immune response.
Research Interests: My group is interested in defining mechanisms that mediate homeostasis between host and microbes at mucosal surfaces. With a main focus on the gastrointestinal tract, our research seeks to provide a better understanding of numerous human diseases, including inflammatory bowel disease, infectious enteritis, necrotizing enterocolitis and others.
Research interests: Inflammation in the central nervous system; the role of microglia in disease progression and the signaling events underlying monocyte to macrophage transformation in the CNS, using retina as a model system.
Research interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.
Research Interests: Mechanisms of signal transduction and information processing by single cells (using a human neutrophil model), cell migration, chemotaxis, neutrophil extracellular trap formation, phagocytosis.
Research interests: My research focuses on sexual dimorphism of the blood- brain barrier +1 BBB microvasculature as a relevant contributor to MS neuropathogenesis with the purpose of developing sex-specific therapeutic targets. Using the chemokine ligand CXCL12, a key regulator of immune trafficking into the central nervous system +1 CNS as a biomarker, we hope to understand how BBB polarity is differentially regulated in females during CNS autoimmunity.
Research interests: Mucosal immunity against pathogens. Molecular Pathogenesis of Human Immunodeficiency Virus +1 HIV and Simian Immunodeficiency Virus +1 SIV Infections with Special Emphasis on Gastrointestinal Mucosal Lymphoid Tissue +1 GALT as a Major Target Organ of the Viral Infection, and as a Viral Reservoir. Repair and renewal of gut mucosal immune system during therapy.
Research Interests: Regenerative medicine, microbiome studies, clinical trials, and developing next-generation tools that can predict/assess response to IBD therapies.
Research interests: mechanisms by which the environment influences susceptibility to immune-mediated disease; identify the mechanisms by which AhR activation leads to divergent CD4+ T cell fates, and test the hypothesis that the interaction between diverse AhR ligands, the host immune system, and the microbiome influences susceptibility to type 1 diabetes.
Research interests: Characterizing the microbiota-gut-brain axis in models of inflammatory bowel disease and following infection with an enteric bacterial pathogen. Determining the mechanisms involved in the development of the microbiota-gut-brain axis in early life.
Research interests: 1. Host response to Bovine and human respiratory syncytial virus: mechanisms of pathogenesis,response to immunomodulation and antiviral therapy, including transcriptome analysis and alteration in immune cell populations. 2. Innate mechanisms of antiviral defense against respiratory viruses in the lung.
Research Interests: Our research is focused on understanding the molecular mechanisms of lung injury diseases and lung cancer. We study ceramide/sphingomyelin signal transduction in stress modulation and apoptosis; molecular mechanisms of nSMase2 and EGFR activation under oxidative stress and TKIs resistance development; and molecular mechanisms of EMT regulated by ceramide metabolites. We use transgenic mice models, animal exposures and imaging, and a range of cell biology and biochemistry methodologies.
Research Interests: Airway inflammation caused by environmental exposures (allergen, cigarette smoke, ozone inhalation, or psychosocial stress) in asthma and COPD. Innate and adaptive immune crosstalk and mechanisms of corticosteroid resistance. Lung physiology and a wide spectrum of immunological cell and molecular biology techniques.
Research Interests: Molecular-to-cellular bioengineering/biomechanics: Our multiscale approach uses the tools of mechanics and high-resolution optical microscopy to deepen the understanding of how nature does things in the nanoworld and where pathogens may attack our natural defenses. On the smallest scale, we characterize isolated single-molecule interactions using ultrasensitive force microscopes.
Research Interests: Leukocyte and cancer cell trafficking. Long standing interest in the role of chemokine receptors, including CCR6 and CXCR4 in immune cells as well as cancer cells.
Research Interests: We study wound repair, using in vitro, animal, and human ex vivo models. Current work: catecholamines, adrenergic receptor signaling and neuroimmune modulation of the wound and its microbiome, generation of an MSC-bioengineered tissue to improve healing. Bench-to-beside translation in our wound clinic.
Research Interests: Our lab has three main areas of focus: 1. Developing an effective HIV vaccine. 2. Understanding mechanisms of HIV susceptibility. 3. Unravelling pathogenesis of neuroinflammation.
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Research Interests: Dr. Ji’s research group is focused on elucidating the epigenetic regulation of chronic diseases such as childhood asthma and examining how epigenetic mechanisms mediate the impact of environmental exposures during critical developmental windows (e.g., infancy) on increased disease susceptibility.
Research Interests: We study innate immune cell responses to infectious disease and malignancy, with a particular focus on natural killer (NK) cells, the third major population of lymphocytes.
Research Interest: 1) Determining the role of monocyte/macrophages in the pathogenesis of infectious diseases, chronic inflammation and aging; 2) Examining the immunology of aging, and; 3) Assessing the roles of macrophages in the pathogenesis of TB using the macaque model of TB/SIV.
Research Interests: Application of combinatorial library methods for basic research and drug discovery, nanotherapeutics, immunotherapeutics, peptide targeted-therapy for cancer, peptide immunochemistry, proteomics, chemical biology, bioconjugate chemistry, substrates and inhibitors for tyrosine kinase, tyrosine sulfotransferases and proteases, development of anti-microbial agents.
Research Interests: Determining the influence of inflammatory cells and cytokines on the structure and function of neurons in the brain and in the lung, and evaluating the role of such interactions in neuro-developmental disorders, neurotoxic syndromes and asthma.
Research Interests: Molecular basis and Immunotherapy of primary biliary cholangitis. Molecular immunology of food allergens and immunotherapy of seafood allergy.
Research Interests: The Immuno-modulatory Biomaterials Laboratory focuses on the development of novel biomaterial systems that can manipulate the immune system. Our primary goal is to design the next generation of immunotherapeutics.
Research Interests: Autoimmunity, basic T cell biology, and cancer immunology. Projects look at the role of glycans in these areas of interest. Other projects focus on utilizing T cell repertoire analysis as a tool to study immune responses.
Research Interests: Cellular and molecular mechanisms of synapse formation, competition, and elimination in the developing visual cortex. The lab studies the formation, persistence, and elimination of individual synapses between dissociated, cultured visual cortical neurons using time-lapse imaging.
Research Interests: Our laboratory focuses on examining T cell response to mucosal pathogens with a view to deepening our understanding of protective immunity and vaccine development.
Research Interests: Our research is focused on understanding the relationship between early life environmental exposures and development of pulmonary disease, such as asthma. We study how mucosal and systemic immunity is established during infancy, and determine the impact of air pollutants, allergens, and infectious disease on childhood lung health.
Research Interests: Use of immunotherapy in cancer, particularly in the context of bone marrow transplantation and using models of metastatic disease. How the immune system normally suppresses itself and how the tumor further suppresses attempts by the immune system to attack it.
Research Interests: Radioimmuotherapy using radionuclide-labelled, cancer-specific monoclonal antibodies for treatment of patients with metastatic breast or prostate cancer, and lymphoma. Use of nude mouse models to explore synergy between this radioimmunotherapy and other drugs. Molecular, genetic changes caused by therapy and their effects on apoptosis. Molecular engineering of new antibody fragments capable of targeting malignant cells.
Research Interests: Dr. Penn’s research focuses on understanding the immune response to Mycobacterium tuberculosis. We use cutting-edge techniques including quantitative mass-spectrometry and CRISPR/Cas9 genome editing to probe the interaction between M. tuberculosis and its host.
Research Interests: Define functional roles for extracellular matrix proteins, with emphasis on the fibronectin family of alternatively spliced proteins, in processes of tissue injury, inflammation and healing. Specifically, to define pathogenetic roles of ECM proteins in osteoarthritis and other chronic inflammatory disorders of aging.
Research Interests: Immunotoxicology of the respiratory system. The effects of environmental air pollutants (gases, vapors, and particles) on lung inflammation and disease. The role of cytokines and growth factors in lung maturation and development. The impact of aerosolized nanomaterials on health and disease.
Research Interests: Multiple sclerosis, experimental autoimmune encephalomyelitis, central nervous system innate immunity, development of the nervous system, neural stem cells.
Research Interests: Interactions between the eukaryotic pathogen Entamoeba histolytica and the human host. The pathogen was named “histolytica” for its ability to destroy host tissues, which is driven by direct killing of human cells. We study how E. histolytica kills cells and invades tissue.
Research Interests: Neurogenic inflammation of the autoimmune diseases psoriasis, psoriatic arthritis, and rheumatoid arthritis. Cell trafficking and the activation of T cells by Nerve Growth Factor during inflammatory reactions. -SCID mouse-human skin chimera model of psoriasis.
Research Interests: My research is focused on understanding the role of the nervous system and neurotransmitters in the modulation of the immune system and inflammation.
Research Interests: Genetics of autoimmunity and autoimmune phenotypes. The primary emphasis is on investigating mouse models of spontaneous polygenic autoimmune syndromes including Type one diabetes, Primary Biliary Cirrhosis, Systemic Lupus Erythematosis and Relapsing Polychondritis.
Research Interests: Post-translational modification of proteins, particularly tyrosine sulfation. Proteins of interest include glycoprotein viral coats, ionotropic and metabotropic glutamate receptors, and G-coupled protein receptors. Collaboration with laboratories which can validate predictions.
Research Interests: We are studying the molecular mechanisms that determine the host range and virulence of viruses by analyzing the interactions of viruses with the host innate immune system. Our long-term goal is to better predict the emergence and threats of newly evolving viruses.
Research Interests: Our focus is the identification of genes of the obligate intracellular parasite Toxoplasma gondii that modulate the host cell and/or determine virulence, host genes and pathways that determine resistance/susceptibility, and to characterize their specific interactions.
Research Interests: Our lab focuses on a better understanding of the control of antibody by investigating transcription factor activity and the architecture of gene regulatory networks in which they are embedded.
Research Interests: My laboratory studies cell-mediated immune responses to HIV-1 and other viruses in mucosal tissues, and immune cell trafficking to the gastrointestinal and reproductive tracts and the central nervous system. Current projects focus on mucosa-associated invariant T-cells (MAIT cells), Tissue-Resident T-cells, and the functionality of cytotoxic T-cells.
Research Interests: Immune modulation by environmental factors (natural glycans such as human milk glycans and pathogen components) and the impact on inflammatory diseases (autoimmune diseases and cancers).
Research Interests: Inflammation in response to acute infection (Staphaureus and MRSA) and chronic disease (Atherosclerosis). Innate immunity of host response. In particular, how neutrophils and monocytes travel from blood out into tissue where they fight infections but can also contribute to disease.
Research Interests: Inflammatory neurological disorders, innate immunity responses within the CNS and how these affect the disease course. Local immune responses in the skin and their effects on injury.
Research Interests: Conducting studies to identify molecular determinants of pathogenesis of feline immunodeficiency virus (FIV) infection in cats and to characterize FIV mutant viruses as attenuated virus vaccines.
Research Interests: My research focuses on the role of nutrition in immune function and resistance to infectious diseases and, conversely, in the impact of infection on nutritional status. Current work focuses on the role of vitamins A and D in T cell-mediated immune responses, and the relationship of gut microbiota to systemic immune activation and vaccine responses, focusing on infants. Other projects also include the impact of omega-3 fatty acids on inflammation.
Research Interests: Developmental, comparative, and clinical immunology with emphasis on bovine, equine, marine mammals, and zoo animal species. Viral and bacterial immunopathogenesis of the fetus and neonate. Immunology of the bovine mammary gland.
Research Interests: Mechanism and regulation of integrin/ligand interactions. Role of integrins in growth factor signaling.
Research Interests: Molecular characterization of food allergens associated with life-threatening anaphylactic reactions. Effect of seed polyphenolics on immune response and the possible role in development of food allergy to peanuts and tree nuts. Cross-reactivity of a food allergy.
Research Interests: Our laboratory is dedicated to the study of tumors that avoid recognition and elimination by the human immune system. We combine modulation of the immune system in the tumor environment with active immunization to treat metastatic cancer. This work involves design, development and testing of peptide immunogens from tumor specific and tumor associated antigens.
Research Interests: My research group studies interactions between bacterial pathogens and the innate immune system. We are particularly interested in how bacterial virulence factors interact with the host to evade immune clearance and elicit pathology.
Research Interests: Development of immune-based therapeutics for B cell malignancies. B lymphocyte signal transduction abnormalities; their role in human disease.
Research Interests: Immunopathology, neuroimmunology, and the cellular and molecular basis of autoimmunity. Current research addresses the biological aspects of autism spectrum disorders including immune function, cellular mechanisms of immune dysregulation, and autoimmunity.
Research Interests: I am interested in the mechanism whereby fusion genes are created. Such genes are classically the driving element in leukemia. However, their significance is expanding to a wider field and such fused genes have been implicated in the development of prostate cancer (TMPRSS2-ERG). Understanding the mechanism behind their creation opens possibilities to suppress the disease they cause.
Research Interests: Roles of airway epithelial cells in lung diseases and airway mucosal immunity, embryonic stem cell biology and regenerative lung biology and medicine, epigenetic mechanism.
Research in immunogenetics, molecular genetics, functional genomics, and bioinformatics in poultry. Focused on elucidating the molecular and cellular mechanisms of host-pathogen interaction including disease resistance, immune response, and pathogenesis of infection. The overall goals are to understand genetic regulation of host response and basic mechanisms of pathogen virulence in animals, to identify host and pathogen genes that are involved in the host-pathogen interplay. The pathogens of interest are food-borne bacteria such as Campylobacter and Salmonella and avian influenza virus.