Faculty

Faculty

Maryam Afkarian, MD, PhD

  • Professor
  • Department of Internal Medicine, Nephrology
  • School of Medicine
Research Interests: Research Interests: mechanistic understanding of inflammation in chronic diseases; specifically understanding the innate and adaptive immune response in diabetic kidney disease (DKD), and characterizing the role of the immune response on DKD pathogenesis. First group to identify an association between urine complement components and progression of diabetic kidney disease (DKD).
451 Health Sciences Drive (GBSF), Room 5404

Tom Ambrosi, PhD

  • Assistant Professor
  • Department of Orthopaedic Surgery
  • School of Medicine
Research Interests: Our lab studies the interactions of skeletal and hematopoietic cellular lineages in postnatal bones of mice and humans using a stem cell-centric approach. Interrogating skeletal stem cell biology during development, aging and cancer/disease allows us to dissect the cellular niches and molecular signals maintaining hematopoietic stem cells and regulating immune cell output. Our long-term goal is to leverage our discoveries to develop strategies to prevent and target skeletal stem cell-based bone aging and hematopoietic malignancies.

Andreas J. Baumler, PhD

  • Professor & Vice Chair
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: PMy laboratory performed pioneering work on understanding the regulation of the composition and function of our microflora by the cells of the intestinal epithelium. We were able to show that cellular respiration of the intestinal cells and their energy metabolism play an essential role in this. If, for example, the intestinal cells change their metabolism during inflammation, the composition of the microflora changes, resulting in so‐called dysbiosis, which can have a decisive influence on the course of the disease, for example in the case of intestinal inflammation, but also in the case of cancer or cardiovascular disease. Our research provides completely new and original starting points for restoring the balance between microflora and the human body in these diseases.
Room 5513
Genome and Biomedical Sciences Facility, University of California Davis, 451 Health Science Dr, Davis CA 95616

Terza Brostoff, DVM, PhD, DACVM

  • Assistant Professor
  • Department of Pathology, Microbiology, and Immunology
  • School of Veterinary Medicine
Research Interests: The Brostoff laboratory develops novel diagnostic tests and vaccines and uses these tools both for clinical application as well as to better study host immune responses to disease. The disease models we are currently studying include feline coronavirus and canine osteosarcoma. We are currently using Raman spectroscopy and machine learning as a platform for novel high-throughput diagnostic test development.
5329 VM3A

Robert Canter, MD

  • Professor and Chair of the Immunology Graduate Group
  • Department of Surgery
  • School of Medicine
Research Interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.
4501 X Street, Suite 3010, Sacramento

Lark Coffey, PhD

  • Professor
  • Department of Pathology, Microbiology & Immunology
  • School of Veterinary Medicine
Research Interest: Research in the Coffey laboratory focuses on the evolution, transmission dynamics, and disease for pathogenic mosquito-borne viruses to understand: (i) patterns of molecular evolution, (ii) viral genetic factors that promote epidemics, (iii) how intrahost genetic diversity generated by error-prone viral replication influences pathogenesis and transmissibility, and (iv) surveillance and vaccine approaches to improve detection and minimize disease.

Sean Collins, PhD

  • Associate Professor
  • Microbiology & Molecular Genetics
  • College of Biological Sciences
Research Interests: My research is focused on the cell biology of immune cells, with a particular focus on neutrophil chemotaxis and degranulation. We use live-cell imaging, molecular biosensors, and optogenetic tools to study single-cell responses.

Lillian Cruz-Orengo, PhD

  • Associate Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: My research focuses on neuro-immune interactions at the blood-brain barrier (BBB) as a relevant contributor to neuroinflammation and consequent neurodegeneration. My long-term goal is to contribute to the identification of non-immunosuppressive and sex-specific therapeutic targets, specifically by elucidating 1) triggering factors of BBB dysfunction, 2) their role in neuropathogenesis and neuroinflammation, and 3) their association with sex-biased autoimmune disorders (e.g. multiple sclerosis).

Satya Dandekar, PhD

  • Professor and Chair
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: Mucosal immunity against pathogens. Molecular Pathogenesis of Human Immunodeficiency Virus +1 HIV and Simian Immunodeficiency Virus +1 SIV Infections with Special Emphasis on Gastrointestinal Mucosal Lymphoid Tissue +1 GALT as a Major Target Organ of the Viral Infection, and as a Viral Reservoir. Repair and renewal of gut mucosal immune system during therapy.

Maneesh Dave, MD, MPH

  • Professor
  • Department of Internal Medicine, Gastroenterology
  • School of Medicine
Research Interests: Regenerative medicine, microbiome studies, clinical trials, and developing next-generation tools that can predict/assess response to IBD therapies.

Vladimir Diaz-Ochoa, PhD

  • Assistant Professor
  • Department of Pathology, Microbiology, and Immunology
  • School of Veterinary Medicine
Research Interests: We have long appreciated the role that neutrophils play as first responders of the immune system during microbial infections. New evidence is emerging on the transcriptomic and phenotypic diversity of this highly abundant circulating white blood cell. In the Diaz-Ochoa lab we combine classical immunological techniques with a systems approach to gain mechanistic insights on the contributions of neutrophil diversity in host responses to bacterial infections.

Allison Ehrlich, PhD

  • Assistant Professor
  • Department of Enviromental Toxicology
  • College of Agricultural and Environmental Sciences
Research Interests: mechanisms by which the environment influences susceptibility to immune-mediated disease; identify the mechanisms by which AhR activation leads to divergent CD4+ T cell fates, and test the hypothesis that the interaction between diverse AhR ligands, the host immune system, and the microbiome influences susceptibility to type 1 diabetes.

Melanie Gareau, PhD

  • Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: My lab studies the development of the microbiota-gut-brain axis. We are interested in understanding the mechanisms of communication between the gut and brain, including the specific neuro, immune, and endocrine pathways involved.
2017 Vet Med 3B

Qizhi Gong, PhD

  • Professor
  • Department of Cell Biology & Human Anatomy
  • School of Medicine
Research Interests: My lab studies the olfactory neuroepithelium as an immune barrier and its involvement in neurodegenerative disease pathogenesis.
3418 Tupper Hall

Angela Haczku, MD, PhD

  • Professor & Associate Dean of Research
  • Pulmonary & Critical Care Medicine
  • School of Medicine
Research Interests: Research in my lab focuses on how the immune system responds to environmental exposures—air pollution (including wildfire smoke), allergens, respiratory viruses and stress — and how these interactions contribute to chronic airway diseases like asthma and COPD. We are particularly interested in innate lymphoid cells, epithelial collectins (surfactant proteins A and D), and the molecular mechanisms that regulate airway inflammation. We use animal models, human studies, and cutting-edge cellular-molecular approaches to find new therapeutic targets and improve respiratory health. My students are exposed to interdisciplinary research, spanning immunology, lung physiology, environmental health, and translational medicine.

Benjamin Hurrell, PhD

  • Assistant Professor
  • Department of Nutrition
  • College of Agricultural and Environmental Sciences
Dr. Hurrell’s lab explores the dynamic interplay between nutrition, metabolism, and immune regulation, focusing on how specific nutrients and metabolic pathways influence the development and function of immune cells in both health and disease, particularly asthma and allergy. Utilizing a variety of cutting-edge mouse models, including genetically engineered strains, specialized diets and established asthma models, his team investigates the impact of dietary factors on immune responses and asthma pathogenesis. By applying techniques such as flow cytometry, transcriptomics, and metabolomics to profile immune cell populations and their metabolic states, the lab aims to identify innovative dietary strategies that can modulate immune function and improve lung health.
Meyer Hall 3143

Hong Ji, PhD

  • Associate Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: Dr. Ji’s research group is focused on elucidating the epigenetic regulation of chronic diseases such as childhood asthma and examining how epigenetic mechanisms mediate the impact of environmental exposures during critical developmental windows (e.g., infancy) on increased disease susceptibility.
California National Primate Research Center

Sean Judge, MD, MS

  • Assistant Professor
  • Department of Surgery
  • School of Medicine
Research Interests: My research aims to understand the interaction between host factors, tissue resident immune cells, and metastasis formation in solid tumors of the GI tract. Specifically, our current work focuses on how obesity may alter liver resident immune cells and augment the metastatic niche in pancreatic cancer. We utilize multiple models and tissues to answer these questions, including cell lines, mouse models, and surgical specimens from patients undergoing surgery.

Jinhwan Kim, PhD

  • Assistant Professor
  • Departments of Biomedical Engineering
  • College of Engineering
  • Department of Surgery
  • School of Medicine
Research Interests: Research Interests: Our research group is dedicated to the engineering of immune cells using biocompatible nanomaterials. One of our primary objectives is to amplify the efficacy of current cancer immunotherapies by enabling real-time, non-invasive, and continuous tracking of these engineered immune cells in vivo. Within the framework of cell-based immunotherapy, we strive to provide comprehensive insights into the location and functionality of immune cells in clinically relevant settings.
UC Davis Health Research Building II

Kit Lam, MD, PhD

  • Distinguished Professor & Department Chair
  • Biochemistry & Molecular Medicine; Hematology & Oncology
  • School of Medicine
Research Interests: Application of combinatorial library methods for basic research and drug discovery, nanotherapeutics, immunotherapeutics, peptide targeted-therapy for cancer, peptide immunochemistry, proteomics, chemical biology, bioconjugate chemistry, substrates and inhibitors for tyrosine kinase, tyrosine sulfotransferases and proteases, development of anti-microbial agents.

Patrick Leung, PhD

  • Recall Adjunct Professor
  • Department of Rheumatology, Allergy & Clinical Immunology
  • School of Medicine
Research Interests: Autoimmune diseases with focus on the molecular basis of primary biliary cholangitis. Food Allergy : Metabolomics and allergen specific immunotherapy in seafood allergy.

Chengfei Liu, MD, PhD

  • Associate Professor
  • Department of Urologic Surgery
  • School of Medicine
Research Interests: The Tan Lab engineers synthetic cells and vesicles for broad biomedical applications, including antibacterial therapy, anticancer treatment, and regenerative medicine. We integrate synthetic genes, proteins, and materials to create new kinds of synthetic cells and vesicles with superior functions to their natural counterparts.
4645 2nd Ave, Research III Bldg, Suite 2300C

Alan Lombard, PhD

  • Assistant Professor
  • Departments of Urologic Surgery and Biochemistry and Molecular Medicine
  • School of Medicine
Research Interests: We are interested in understanding how tumor cells adapt to therapy. We largely study drug tolerant persistence, which is thought to describe a state of transient insensitivity which provides a repository of surviving tumor cells which may develop resistance and drive progression. These cells are thought to co-opt the tumor microenvironment to survive, and one area of interest is investigating how drug tolerant persistent cells evade immunosurveillance.
Oak Park Research Bldg Rm 2102B

Emanual Maverakis, MD

  • Professor
  • Department of Dermatology
  • School of Medicine
Research Interests: Autoimmunity, basic T cell biology, and cancer immunology. Projects look at the role of glycans in these areas of interest. Other projects focus on utilizing T cell repertoire analysis as a tool to study immune responses.

Steven McElroy, MD

  • Professor and Division Chief of Neonatology
  • Department of Pediatrics
  • School of Medicine
Research Interests: Dr. McElroy has a long-standing interest in understanding the injury and repair mechanisms of the developing small intestine, specifically how these relate to neonatal necrotizing enterocolitis. His laboratory has made seminal discoveries linking Paneth cells and goblet cells to the protection of the immature intestinal tract, has developed novel complementary models of necrotizing enterocolitis that shed light on pathways to develop the disease, has investigated the link between maternal chorioamnionitis and subsequent intestinal disease in offspring, and is now looking at the link between total body sodium and neonatal sepsis. Dr. McElroy has received funding from the NIH, the Children’s Miracle Network, and industry partners.

Lisa Miller, PhD

  • Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: Our research is focused on understanding the relationship between early life environmental exposures and development of pulmonary disease, such as asthma. We study how mucosal and systemic immunity is established during infancy, and determine the impact of air pollutants, allergens, and infectious disease on childhood lung health.
California National Primate Research Center

Jan Nolta, PhD

  • Professor
  • Department of Cell Biology & Human Anatomy
  • School of Medicine
Research Interests: As a translational scientist, I work with MDs toward clinical trials of immunotherapy. I am scientific director of our Good Manufacturing Practice Facility and director of our cell and gene therapy program. our team works on CAR-T development, manufacturing and delivery in clinical trials.
2921 Stockton Blvd, Suite 1300, Sacramento

Bennett Penn, MD, PhD

  • Associate Professor
  • Department of Internal Medicine, Infectious Diseases
  • School of Medicine
Research Interests: Dr. Penn’s research focuses on understanding the immune response to Mycobacterium tuberculosis. We use cutting-edge techniques including quantitative mass-spectrometry and CRISPR/Cas9 genome editing to probe the interaction between M. tuberculosis and its host.

David Pleasure, MD

  • Distinguished Professor Emeritus
  • Department of Neurological Surgery
  • School of Medicine
Research Interests: My research centers on central nervous system glial development and glial diseases.

Colin Reardon, PhD

  • Associate Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: Focusing on how bidirectional communication between the nervous and immune system alters immune outcomes in gut and lung.
Room 2007, Vet Med 3B

Robert Rebhun, DVM, PhD

  • Professor
  • Department of Surgical & Radiological Sciences
  • School of Veterinary Medicine
Research Interests: Comparative oncology, canine cancer immunology, metastasis, sarcoma, melanoma.
217 Center for Companion Animal Health

Grace Rosenquist, PhD

  • Assistant Adjunct Professor
  • Department of Neurobiology, Physiology & Behavior
  • College of Biological Sciences

Stefan Rothenburg, MD, PhD

  • Professor
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: Our lab is studying the consequences of evolutionary arms races between viruses and their hosts. We are especially interested in how the interaction between viruses, and the innate immune system of their hosts influences the host range and virulence of viruses.
3141 Tupper Hall

Hannah Savage, DVM, PhD

  • Assistant Professor
  • Department of Pathology, Microbiology, and Immunology
  • School of Veterinary Medicine
Research Interests: The Savage lab studies interactions between pathogens, the microbiota, and host. In particular, I currently focus on how the microbiota promotes a heathy colonocyte immunometabolism and how this interaction is altered during disease, putting the host at risk of infection with pathogens and pathobionts. My overall research goal is to understand the basis behind these host-microbiota interactions during health so that host health can be supported with therapeutics during microbial disruption to prevent a loss of colonization resistance.

Roger Sciammas, PhD

  • Associate Professor
  • Department of Anatomy, Physiology & Cell Biology
  • School of Veterinary Medicine
Research Interests: Antibody production requires B cell maturation coordinated by changes in transcriptional and post-transcriptional mechanisms of gene expression. The lab studies the transcription factors and RNA binding proteins that drive maturation into antibody secreting plasma cells.

Barbara Shacklett, PhD

  • Professor
  • Department of Medical Microbiology & Immunology
  • Department of Infectious Disease
  • School of Medicine
Research Interests: My lab focuses mainly on mucosal immunity in chronic HIV infection, with an emphasis on the gastrointestinal and reproductive tracts. Topics of interest include tissue-resident T-cells, regulatory T-cells (Treg), mucosa-associated invariant T-cells (MAIT) and the contributions of these cell types to host defense against mucosal pathogens.
3327 Tupper Hall

Sasha Shafikhani, PhD

  • Professor
  • Department of Dermatology
  • School of Medicine
Research Interests: As a cellular microbiologist, my research focuses on leveraging insights from pathogen studies to deepen our understanding of host cellular processes. My lab's primary aim is to uncover the virulence mechanisms driving Pseudomonas aeruginosa pathogenesis in wound infections, as well as the eukaryotic host responses designed to control these infections. We also utilize bacterial toxins as molecular tools to explore key mammalian cellular processes, including cell cycle regulation, cytokinesis, programmed cell death (apoptosis), and apoptotic compensatory proliferation signaling. A particular area of interest for us is the innate immune dysregulation that makes diabetic wounds susceptible to infection and impairs healing. In addition, we have identified critical innate immune pathways that recognize P. aeruginosa and investigated how this pathogen suppresses these immune responses. Additionally, we explore the use of immunomodulators to enhance innate immune responses as a strategy for combating infections at surgical sites.
Institute of Regenerative Cures (IRC); 2921 Stockton Blvd, Sacramento, CA

Ryan Snodgrass, PhD

  • Adjunct Assistant Professor
  • Department of Nutrition
  • College of Agricultural and Environmental Sciences
Research Interests: Dr. Snodgrass’s research is focused on understanding how diet and nutritional and metabolic status shape immune function. Active research areas include (1) investigating the impact of diet and stress on cardiovascular risk factors and immune cell function in human subjects, and (2) understanding how gut microbiota and their metabolites, both of which are influenced by diet, contribute to host immunity.
USDA Western Human Nutrition Research Center

Cheemeng Tan, PhD

  • Professor
  • Department of Biomedical Engineering
  • College of Engineering
Research Interests: The Tan Lab engineers synthetic cells and vesicles for broad biomedical applications, including antibacterial therapy, anticancer treatment, and regenerative medicine. We integrate synthetic genes, proteins, and materials to create new kinds of synthetic cells and vesicles with superior functions to their natural counterparts.
GBSF2220 (Lab), GBSF2321 (Office), University of California Davis

Christine Toedebusch, DVM, PhD

  • Associate Professor
  • Department of Surgical & Radiological Sciences
  • School of Veterinary Medicine
Research Interests: Dr. Toedebusch is a veterinary neurologist and comparative neuro-oncologist dedicated to improving the lives of humans and dogs with brain tumors. She combines her clinical expertise and scientific training to 1) advance understanding of the translational relevance of spontaneously occurring high-grade glioma as a model for human disease and 2) Uncover the molecular mechanisms of immunosuppression in high-grade glioma. Dr. Toedebusch collaborates with a multidisciplinary team of scientists and physicians to develop and test innovative therapies through clinical trials in canine patients. Her ultimate goal is to discover new treatments for brain tumors that benefit both dogs and humans—advancing care and quality of life across species.

Jose Torres, PhD

  • Professor
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: Improvement of cancer immunotherapy and development of cancer vaccines.

Renee Tsolis, PhD

  • Professor
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: The Tsolis lab utilizes intracellular bacteria, particularly Salmonella, Brucella, and more recently Chlamydia, to study functioning of the host innate immune system as well as how microbial communities at mucosal surfaces protect against infection. One question the lab has been addressing is how host phagocytes detect subversion of their physiology by injected virulence factors of intracellular pathogens, which led to discovery of a new function for NOD1 and NOD2 in sensing endoplasmic reticulum stress induced by Chlamydia and Brucella. The lab’s work on Salmonella has advanced our understanding of how underlying comorbidities prevalent in the developing world, such as malaria and malnutrition, compromise phagocyte functions required for containment of infection to the gastrointestinal tract, thereby increasing susceptibility to disseminated infection. Most recently the lab has focused on animal modeling to generate a model to study typhoid fever, an infection that is strictly restricted to humans.

Jogender Tushir-Singh, PhD

  • Associate Professor
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research interests: Our laboratory focuses on the design and application of antibodies and CARs in improving Cancer immunotherapy. We are also interested in identifying regulatory mechanisms in the Cancer-Tumor microenvironment that could interfere with the efficacy of T-cell-based immunotherapy.
3437 Tupper Hall, UC Davis 95616

Rodolfo Urbano, PhD

  • Assistant Professor
  • Department of Pathology, Microbiology, and Immunology
  • School of Veterinary Medicine
Research Interests: The Urbano Lab studies microbial-host interactions that involve the actin cytoskeleton. Immune signals such as IFN-g activate host cells to fight infection by stimulating expression of cellular defenses that include actin-binding proteins (ABPs). Our lab aims to characterize the functions of these ABPs in the context of the immune response and learn how actin-based immunity impacts microbial pathogenesis and pathogen clearance. One area of active research involves the role of ABPs in microbial actin-based motility and cell-to-cell dissemination (Listeria, Shigella, Burkholderia, etc.). Additionally, ABPs are important components of the host cell adhesion and motility machinery. Here we aim to understand how immune activation modifies the mechanical properties of cells to mobilize to sites of infection, capture and eliminate microbes.
Vet Med 3A, Rm.3327

Judy Van de Water, PhD

  • Professor
  • Department of Rheumatology
  • School of Medicine
Research Interests: My research is focused on clinical immunology, neuroimmunology and autoimmunity. The current projects include the immunobiology of neurodevelopmental disorders including autism and schizophrenia. We are also interested in the maternal gestational immune environment and how dysregulation of the maternal immune system impacts offspring development.
The MIND Institute & 6510 GBSF

Natalia Vapniarsky, DVM, PhD

  • Associate Professor
  • Department of Pathology, Microbiology and Immunology
  • School of Veterinary Medicine
Research Interests: My research is focused on immunological hurdles in regenerative medicine. Specifically, my lab has determined that some cells may not be immunoprivileged, as previously prescribed by a well-accepted dogma. Hence, my team is assessing the relevance of MHC-I matching in stem cell therapy and musculoskeletal transplantation.
Vet Med 3A

Siao-Yi Wang, MD, PhD

  • Assistant Professor
  • Department of Oncology, Hematology/Oncology
  • School of Medicine
My research interests are primarily in adoptive T-cell therapy (ACT) for solid tumors. While ACT has demonstrated impressive results in hematologic malignancies, success has been limited in solid tumors. I am investigating ways to improve ACT through novel methods of generating genetically-modified cells and through modulating the tumor immune microenvironment.
Aggie Square, Rm 3710

Sebastian Winter, PhD

  • Associate Professor
  • Department of Infectious Disease
  • Department of Medical Microbiology & Immunology
  • School of Medicine
Research Interests: The Winter lab studies the chemical biology of host-microbe interactions, with a focus on gastrointestinal inflammatory diseases, such as enteric infections, inflammatory bowel disease, and colitis-associated colorectal cancer. The lab is investigating how the immune system shapes the metabolism of the gut microbiota, and vice versa. A better understanding of host-microbiota interactions is expected to aid in the development of novel, microbiota-targeting intervention strategies for inflammatory diseases.

Anthony Zamora, PhD

  • Associate Professor
  • Department of Internal Medicine
  • School of Medicine
Research Interests: Research in the Zamora Lab focuses on cancer immunology, with an emphasis on developing strategies to modulate the immune system for more precise and effective elimination of cancer cells. We employ cellular engineering techniques to enhance immune cell specificity while minimizing off-target toxicities. Our work integrates advanced single-cell technologies to profile the phenotypic, functional, and receptor repertoires of neoantigen-specific T cells.
2921 Stockton Blvd, Office 1614, Sacramento, CA

Huaijun Zhou, PhD

  • Professor
  • Department of Animal Science
  • College of Agricultural and Environmental Sciences
Research Interests: Research in immunogenetics, molecular genetics, functional genomics, and bioinformatics in poultry. My group is focused on elucidating the molecular and cellular mechanisms of host-pathogen interaction including disease resistance, immune response, and pathogenesis of infection.
2247 Meyer Hall

Angela Zivkovic, PhD

  • Associate Professor
  • Department of Nutrition
  • College of Agricultural and Environmental Sciences
Research Interests: the immunomodulatory effects of foods, food components, food-and gut microbiome-derived molecules, and high density lipoprotein (HDL) particles. We are particularly interested in the interactions between diet and the gut-brain axis, including intestinally-derived HDL particles and their cargo such as carotenoids, and their relationship with innate immune cells involved in the pathophysiology of neurodegenerative disease, particularly Alzheimer's disease.
3245 Meyer Hall