Innate Immunology

Research Interests: We have long appreciated the role that neutrophils play as first responders of the immune system during microbial infections. New evidence is emerging on the transcriptomic and phenotypic diversity of this highly abundant circulating white blood cell. In the Diaz-Ochoa lab we combine classical immunological techniques with a systems approach to gain mechanistic insights on the contributions of neutrophil diversity in host responses to bacterial infections.

Research Interests: My lab studies the olfactory neuroepithelium as an immune barrier and its involvement in neurodegenerative disease pathogenesis.

Research Interests: Research Interests: mechanistic understanding of inflammation in chronic diseases; specifically understanding the innate and adaptive immune response in diabetic kidney disease (DKD), and characterizing the role of the immune response on DKD pathogenesis. First group to identify an association between urine complement components and progression of diabetic kidney disease (DKD).

Research Interests: Dr. McElroy has a long-standing interest in understanding the injury and repair mechanisms of the developing small intestine, specifically how these relate to neonatal necrotizing enterocolitis. His laboratory has made seminal discoveries linking Paneth cells and goblet cells to the protection of the immature intestinal tract, has developed novel complementary models of necrotizing enterocolitis that shed light on pathways to develop the disease, has investigated the link between maternal chorioamnionitis and subsequent intestinal disease in offspring, and is now looking at the link between total body sodium and neonatal sepsis. Dr. McElroy has received funding from the NIH, the Children’s Miracle Network, and industry partners.

Research Interests: Tissue engineering, osteoimmunology, role of immune system on tissue repair and regeneration.

Research Interests: Dr. Penn’s research focuses on understanding the immune response to Mycobacterium tuberculosis. We use cutting-edge techniques including quantitative mass-spectrometry and CRISPR/Cas9 genome editing to probe the interaction between M. tuberculosis and its host.

Research Interests: Cancer immunotherapy, viral immunology, preclinical modeling.

Research Interests: Research in my lab focuses on how the immune system responds to environmental exposures—air pollution (including wildfire smoke), allergens, respiratory viruses and stress — and how these interactions contribute to chronic airway diseases like asthma and COPD. We are particularly interested in innate lymphoid cells, epithelial collectins (surfactant proteins A and D), and the molecular mechanisms that regulate airway inflammation. We use animal models, human studies, and cutting-edge cellular-molecular approaches to find new therapeutic targets and improve respiratory health. My students are exposed to interdisciplinary research, spanning immunology, lung physiology, environmental health, and translational medicine.

Research Interests: Dr. Ji’s research group is focused on elucidating the epigenetic regulation of chronic diseases such as childhood asthma and examining how epigenetic mechanisms mediate the impact of environmental exposures during critical developmental windows (e.g., infancy) on increased disease susceptibility.