Clinical Immunology

Research Interests: The Brostoff laboratory develops novel diagnostic tests and vaccines and uses these tools both for clinical application as well as to better study host immune responses to disease. The disease models we are currently studying include feline coronavirus and canine osteosarcoma. We are currently using Raman spectroscopy and machine learning as a platform for novel high-throughput diagnostic test development.

Research Interests: The Savage lab studies interactions between pathogens, the microbiota, and host. In particular, I currently focus on how the microbiota promotes a heathy colonocyte immunometabolism and how this interaction is altered during disease, putting the host at risk of infection with pathogens and pathobionts. My overall research goal is to understand the basis behind these host-microbiota interactions during health so that host health can be supported with therapeutics during microbial disruption to prevent a loss of colonization resistance.

Research Interests: As a translational scientist, I work with MDs toward clinical trials of immunotherapy. I am scientific director of our Good Manufacturing Practice Facility and director of our cell and gene therapy program. our team works on CAR-T development, manufacturing and delivery in clinical trials.

Research Interests: Research Interests: mechanistic understanding of inflammation in chronic diseases; specifically understanding the innate and adaptive immune response in diabetic kidney disease (DKD), and characterizing the role of the immune response on DKD pathogenesis. First group to identify an association between urine complement components and progression of diabetic kidney disease (DKD).

Research Interests: Autoimmunity, Type 1 Diabetes, T cells, Myeloid derived suppressor cells.

Research Interests: Translational research in cross-species phenotype and function of NK cells and NK targeting of cancer stem cells.

Research Interests: Cancer immunotherapy, viral immunology, preclinical modeling.